Besieging \/\/FREE\\\\
Disease was another effective siege weapon, although the attackers were often as vulnerable as the defenders. In some instances, catapults or similar weapons were used to fling diseased animals over city walls in an early example of biological warfare. If all else failed, a besieger could claim the booty of his conquest undamaged, and retain his men and equipment intact, for the price of a well-placed bribe to a disgruntled gatekeeper. The Assyrian siege of Jerusalem in the 8th century BC came to an end when the Israelites bought them off with gifts and tribute, according to the Assyrian account, or when the Assyrian camp was struck by mass death, according to the Biblical account. Due to logistics, long-lasting sieges involving a minor force could seldom be maintained. A besieging army, encamped in possibly squalid field conditions and dependent on the countryside and its own supply lines for food, could very well be threatened with the disease and starvation intended for the besieged.
besieging
To end a siege more rapidly, various methods were developed in ancient and medieval times to counter fortifications, and a large variety of siege engines was developed for use by besieging armies. Ladders could be used to escalade over the defenses. Battering rams and siege hooks could also be used to force through gates or walls, while catapults, ballistae, trebuchets, mangonels, and onagers could be used to launch projectiles to break down a city's fortifications and kill its defenders. A siege tower, a substantial structure built to equal or greater height than the fortification's walls, could allow the attackers to fire down upon the defenders and also advance troops to the wall with less danger than using ladders.
Once siege guns were developed, the techniques for assaulting a town or fortress became well known and ritualized. The attacking army would surround a town. Then the town would be asked to surrender. If they did not comply, the besieging army would surround the town with temporary fortifications to stop sallies from the stronghold or relief getting in. The attackers would next build a length of trenches parallel to the defences (these are known as the "First parallel") and just out of range of the defending artillery. They would dig a trench (known as a Forward) towards the town in a zigzag pattern so that it could not be enfiladed by defending fire. Once they were within artillery range, they would dig another parallel (the Second Parallel) trench and fortify it with gun emplacements. This technique is commonly called entrenchment.
In the 1530s and '40s, the new style of fortification began to spread out of Italy into the rest of Europe, particularly to France, the Netherlands, and Spain. Italian engineers were in enormous demand throughout Europe, especially in war-torn areas such as the Netherlands, which became dotted by towns encircled in modern fortifications. The densely populated areas of Northern Italy and the United Provinces (the Netherlands) were infamous for their high degree of fortification of cities. It made campaigns in these areas very hard to successfully conduct, considering even minor cities had to be captured by siege within the span of the campaigning season. In the Dutch case, the possibility of flooding large parts of the land provided an additional obstacle to besiegers, for example at the siege of Leiden. For many years, defensive and offensive tactics were well balanced, leading to protracted and costly wars such as Europe had never known, involving more and more planning and government involvement. The new fortresses ensured that war rarely extended beyond a series of sieges. Because the new fortresses could easily hold 10,000 men, an attacking army could not ignore a powerfully fortified position without serious risk of counterattack. As a result, virtually all towns had to be taken, and that was usually a long, drawn-out affair, potentially lasting from several months to years, while the members of the town were starved to death. Most battles in this period were between besieging armies and relief columns sent to rescue the besieged.
At the end of the 17th century, two influential military engineers, the French Marshal Vauban and the Dutch military engineer Menno van Coehoorn, developed modern fortification to its pinnacle, refining siege warfare without fundamentally altering it: ditches would be dug; walls would be protected by glacis; and bastions would enfilade an attacker. Both engineers developed their ideas independently, but came to similar general rules regarding defensive construction and offensive action against fortifications. Both were skilled in conducting sieges and defences themselves. Before Vauban and Van Coehoorn, sieges had been somewhat slapdash operations. Vauban and Van Coehoorn refined besieging to a science with a methodical process that, if uninterrupted, would break even the strongest fortifications. Examples of their styles of fortifications are Arras (Vauban) and the no-longer-existent fortress of Bergen op Zoom (Van Coehoorn). The main differences between the two lay in the difference in terrain on which Vauban and Van Coehoorn constructed their defences: Vauban in the sometimes more hilly and mountainous terrain of France, Van Coehoorn in the flat and floodable lowlands of the Netherlands.
Planning and maintaining a siege is just as difficult as fending one off. A besieging army must be prepared to repel both sorties from the besieged area and also any attack that may try to relieve the defenders. It was thus usual to construct lines of trenches and defenses facing in both directions. The outermost lines, known as the lines of contravallation, would surround the entire besieging army and protect it from attackers.
This would be the first construction effort of a besieging army, built soon after a fortress or city had been invested. A line of circumvallation would also be constructed, facing in towards the besieged area, to protect against sorties by the defenders and to prevent the besieged from escaping. The next line, which Vauban usually placed at about 600 meters from the target, would contain the main batteries of heavy cannons so that they could hit the target without being vulnerable themselves. Once this line was established, work crews would move forward, creating another line at 250 meters. This line contained smaller guns. The final line would be constructed only 30 to 60 meters from the fortress. This line would contain the mortars and would act as a staging area for attack parties once the walls were breached. Van Coehoorn developed a small and easily movable mortar named the coehorn, variations of which were used in sieges until the 19th century. It would also be from this line that miners working to undermine the fortress would operate.
An important element of strategy for the besieging army was whether or not to allow the encamped city to surrender. Usually, it was preferable to graciously allow a surrender, both to save on casualties, and to set an example for future defending cities. A city that was allowed to surrender with minimal loss of life was much better off than a city that held out for a long time and was brutally butchered at the end. Moreover, if an attacking army had a reputation of killing and pillaging regardless of a surrender, then other cities' defensive efforts would be redoubled. Usually, a city would surrender (with no honour lost) when its inner lines of defence were reached by the attacker. In case of refusal, however, the inner lines would have to be stormed by the attacker and the attacking troops would be seen to be justified in sacking the city.
The policy of besieging Palestinian villages, towns and cities is part of the collective sanctions that Israel uses against Palestinians. The Israeli army had resorted to this policy during the 2000 intifada, separating the Palestinian communities from each other with military checkpoints, earth mounds and concrete blocks.
Shalhat added that there is a state of confusion among the Israeli security establishments about ways to deal with the situation in the West Bank, and the army is thus resorting to besieging cities and villages in light of its failure to end the state of resistance.
The military sense, "the stationing of an attacking force before or around a fortified place; the act or process of besieging a city, castle, etc." is attested from c. 1300; the notion is of an army "sitting down" before a place.
Based on these constatations, an alternative approach of besieging the tumoral lesions by reinforcement of the surrounding desmoplasia with immune cells, mainly macrophages, is proposed. The choice of macrophages is inspired by granulomatous reaction constated in some tumoral lesions. Some authors have found a better prognosis in some tumors [20-21], while others have not [22]. As we did not find a report concerning their presence in PDAC, some cases with favorable outcomes of granuloma associated with signet ring cell gastric carcinoma, which have also prominent desmoplasia, had been reported [23-24]. Macrophage attraction to tumoral sites is induced by the secretion of chemokines in the milieu, such as chemokine (C-C motif) ligand 5 (CCL5), which also has a role in granuloma formation [25]. It may be upregulated by some cytokines, such as interleukin 1 beta (IL-1β), interferon-gamma (IFNγ), tumor necrosis factor-alpha (TNFα), and interleukin 32γ (IL-32γ) [26-27]. IL-1β has been used for the treatment of solid tumors (given experimentally) reducing effects on tumor growth, and an increase of lymphocytes and inflammatory cells influx into the tumor [28]. Some phase I/II clinical trials have shown regression of tumors, although the response was not consistent. However, the use of IL-1β was limited due to high systemic toxicity, making this method unlikely to be applicable unless a method of local enhancement of IL-1β is implemented [28].
In this world, we would not have to put our faith in the vast, stratified system of corporatized and financialized American higher education. We do not have to accept the continued existence of this system. We can change it for the better, and besieging the Ivy League is a good start. 041b061a72